I didn't buzz through all the pages, but it sounds like you're thinking revolver, and that's great. Look into J-Frame Smith's, the LCR Ruger, or even the SP101 Ruger which are all good revolvers.

I will ask why you think you want something 10oz or lighter? Have you pocket carried one for any duration or just from reading made this decision? Lots of good reliable guns fit your need. When you go light weight, you gain felt recoil, it's a balancing act of comfort.

I'm not sure I myself would want to rely on carrying something in .22, but I won't volunteer to stand in front of you while you pop a few off either. If I were to carry daily, , either my Springfield XD 9mm Sub Compact or my full size 1911 in 45 due to not owning a pocket revolver. However, a pocket revolver is on my list, more specifically the Ruger SP101. It's heavy, but I wear a good belt, and with a good pocket holster, seems fine from my test runs. Also a nice IWB holster makes them disappear just fine too.

Food for thought, good luck with your decision.