CUDA
04-17-2025, 03:39 AM
https://www.politico.eu/article/bas-bloem-parkinsons-pesticides-mptp-glyphosate-paraquat/
In the summer of 1982, seven heroin users were admitted to a California hospital paralyzed and mute. They were in their 20s, otherwise healthy — until a synthetic drug they had manufactured in makeshift labs left them frozen inside their own bodies. Doctors quickly discovered the cause: MPTP, a neurotoxic contaminant that had destroyed a small but critical part of the brain, the substantia nigra, which controls movement.
The patients had developed symptoms of late-stage Parkinson’s, almost overnight.
The cases shocked neurologists. Until then, Parkinson’s was thought to be a disease of aging, its origins slow and mysterious. But here was proof that a single chemical could reproduce the same devastating outcome. And more disturbing still: MPTP turned out to be chemically similar to paraquat, a widely used weedkiller that, for decades, had been sprayed on farms across the United States and Europe.
“Parkinson’s is a man-made disease,” he says. “And the tragedy is that we’re not even trying to prevent it.”
When the English surgeon James Parkinson first described the “shaking palsy” in 1817, it was considered a medical curiosity — a rare affliction of aging men. Two centuries later, Parkinson’s disease has more than doubled globally over the past 20 years, and is expected to double again in the next 20. It is now one of the fastest-growing neurological disorders in the world, outpacing stroke and multiple sclerosis. The disease causes the progressive death of dopamine-producing neurons and gradually robs people of movement, speech and, eventually, cognition. There is no cure.
Age and genetic predisposition play a role. But Bloem and the wider neurological community contend that those two factors alone cannot explain the steep rise in cases. In a 2024 paper co-authored with U.S. neurologist Ray Dorsey, Bloem wrote that Parkinson’s is “predominantly an environmental disease” — a condition shaped less by genetics and more by prolonged exposure to toxicants like air pollution, industrial solvents and, above all, pesticides.
In the summer of 1982, seven heroin users were admitted to a California hospital paralyzed and mute. They were in their 20s, otherwise healthy — until a synthetic drug they had manufactured in makeshift labs left them frozen inside their own bodies. Doctors quickly discovered the cause: MPTP, a neurotoxic contaminant that had destroyed a small but critical part of the brain, the substantia nigra, which controls movement.
The patients had developed symptoms of late-stage Parkinson’s, almost overnight.
The cases shocked neurologists. Until then, Parkinson’s was thought to be a disease of aging, its origins slow and mysterious. But here was proof that a single chemical could reproduce the same devastating outcome. And more disturbing still: MPTP turned out to be chemically similar to paraquat, a widely used weedkiller that, for decades, had been sprayed on farms across the United States and Europe.
“Parkinson’s is a man-made disease,” he says. “And the tragedy is that we’re not even trying to prevent it.”
When the English surgeon James Parkinson first described the “shaking palsy” in 1817, it was considered a medical curiosity — a rare affliction of aging men. Two centuries later, Parkinson’s disease has more than doubled globally over the past 20 years, and is expected to double again in the next 20. It is now one of the fastest-growing neurological disorders in the world, outpacing stroke and multiple sclerosis. The disease causes the progressive death of dopamine-producing neurons and gradually robs people of movement, speech and, eventually, cognition. There is no cure.
Age and genetic predisposition play a role. But Bloem and the wider neurological community contend that those two factors alone cannot explain the steep rise in cases. In a 2024 paper co-authored with U.S. neurologist Ray Dorsey, Bloem wrote that Parkinson’s is “predominantly an environmental disease” — a condition shaped less by genetics and more by prolonged exposure to toxicants like air pollution, industrial solvents and, above all, pesticides.